关键词: 大蒜素, tau转基因小鼠, p-tau, 氧化应激

Abstract: In this study,the effect of allicin on the expression of tau protein phosphorylated in the brain of transgenic mice was investigated by immunofluorescence and Western blot method.The SOD activity and MDA content in the brain of wild type,tau transgenic mice and the treatment group mice were detected.The results showed that the activity of superoxide dismutase(SOD) in the allicin administration mice brain was increased compared to that of AD model mice,and the content of MDA was reduced;Hyperphosphorylation of tau protein were changed at ser202,ser404,ser396,Thr181 site in the transgenic mice brain,but the hyperphosphorylation of tau protein was significantly reduced in the transgenic mice treated with allicin.These results indicated that allicin decreased oxidative stress effect in AD mice brain through its powerful antioxidant activity,and hence declined the level of tau protein phosphorylation in AD mice brain.These results suggested that allicin had potential value for the clinical treatment of AD.

Key words: Allicin, tau transgenic mice, p-tau, oxidative stress