To clarify the total polyphenol content (TPC) and antioxidant/anti-inflammatory activities of Cichorium intybus L.,this study used the aboveground parts,leaves,and processed tea products of C.intybus as raw materials,with water or ethanol as solvents for reflux extraction.The extracts were then processed by D101 macroporous resin method or solvent method to obtain solid extracts.The Folin-Ciocalteu method was employed to determine total polyphenol content,the DPPH and ABTS assays were used to evaluate in vitro antioxidant activities,and Griess and ELISA methods were applied to assess the effects of the extracts on lipopolysaccharide (LPS)-induced nitric oxide (NO) and interleukin-6 (IL-6) release in macrophage RAW 264.7 cells.Experimental results showed that among all the extracts,the D101 resin-purified leaf extract (CIE-11) exhibited the highest total polyphenol content (50.6%) and the strongest antioxidant activity (IC₅₀=6.0 μg/mL by DPPH assay;IC₅₀=1.835 μg/mL by ABTS assay).Correlation analysis between TPC and antioxidant activity revealed a significant positive correlation.Further cellular experiments demonstrated that CIE-11 significantly inhibited LPS-induced NO and IL-6 release in mouse macrophage RAW 264.7 cells,indicating its potential anti-inflammatory pharmacological activity.This study provides a reference for the application of chicory in anti-inflammatory and antioxidant fields,as well as for drug development.