茶油促进脱毛小鼠毛发生长的药效及机制研究

天然产物研究与开发 ›› 2025, Vol. 37 ›› Issue (增刊1): 16-27.

茶油促进脱毛小鼠毛发生长的药效及机制研究

陈圣棠1，黄志平2，王宇晖3，陈先毅4*，徐笑天3*

1广东油中之花生物科技有限公司，东莞 523710；2广西壮族自治区森林资源与生态环境监测中心，南宁 530029；3桂林医科大学药学院，桂林 541199；4防城港市防城区街道水产畜牧兽医站，防城港 538021

出版日期:2025-09-25 发布日期:2025-09-22
基金资助:
国家自然科学基金（82360646）

Pharmacodynamics and mechanism of camellia oil in promoting hair growth of depilated mice

CHEN Sheng-tang1,HUANG Zhi-ping2,WANG Yu-hui3,CHEN Xian-yi4*,XU Xiao-tian3*

1Guangdong Youzhongzhihua Biotechnology Co.,Ltd.,Dongguan 523710,China;2Forest Resources and Ecological Environment Monitoring Center of Guangxi Zhuang Autonomous Region,Nanning 530029,China;3School of Pharmacy,Guilin Medical University,Guilin 541199,China;4Aquatic Products and Animal Husbandry Veterinary Station,Sub-district of Fangcheng District,Fangchenggang 538021,China

Online:2025-09-25 Published:2025-09-22

摘要/Abstract

摘要：

评价茶油对脱毛小鼠毛发再生的促进效果并探究其机制。以C57BL/6J雄性小鼠为实验对象，分为4组：正常组、对照组、茶油组及米诺地尔组，采用松香石蜡法建立脱毛小鼠模型。按照分组每日涂抹相应试剂于小鼠脱毛区皮肤，连续涂抹21 d。通过对比各组再生毛发生长评分、毛长、毛重、毛囊数量的差异来研究茶油对毛发生长的促进作用。采用网络药理学及分子对接，探究茶油促进毛发生长的作用靶点及相关通路。采用qPCR法检测相关靶点基因表皮生长因子（epidermal growth factor receptor，EGFR）的表达情况。研究结果表明，茶油能显著促进脱毛小鼠毛发生长，具体体现在茶油促进脱毛小鼠毛发生长评分增加，再生毛长、毛重增加，毛囊数量增加。其机制可能通过靶向EGFR，上调EGFR水平来实现。

关键词: 茶油, 毛发生长, 毛囊, 表皮生长因子受体

Abstract:

This study aims to evaluate the promoting effect of camellia oil on hair regrowth in depilated mice and explores its mechanism.Male C57BL/6J mice were used as experimental subjects and divided into four groups:the normal group,the control group,the minoxidil group,and the camellia oil group.A depilated mice model was established using the rosin paraffin method.The corresponding reagents were applied to the skin of the depilated area of the mice every day for 21 consecutive days.By comparing the differences in the scores of regrowth hair,hair length,hair weight,and hair follicle numbers among the groups,the promoting effect of camellia oil on hair growth was studied.Network pharmacology and molecular docking were used to explore the target sites and related pathways of camellia oil in promoting hair growth.The expression of the related target gene epidermal growth factor receptor (EGFR) was detected using qPCR.The results showed that camellia oil could significantly promote hair growth in depilated mice,and its mechanism may be achieved by targeting EGFR and upregulating EGFR levels.

Key words: camellia oil, hair growth, hair follicles, epidermal growth factor receptor

中图分类号: R285.5

陈圣棠, 黄志平, 王宇晖, 陈先毅, 徐笑天. 茶油促进脱毛小鼠毛发生长的药效及机制研究[J]. 天然产物研究与开发, 2025, 37(增刊1): 16-27.

CHEN Sheng-tang, HUANG Zhi-ping, WANG Yu-hui, CHEN Xian-yi, XU Xiao-tian. Pharmacodynamics and mechanism of camellia oil in promoting hair growth of depilated mice[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(增刊1): 16-27.

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