天然产物研究与开发 ›› 2025, Vol. 37 ›› Issue (7): 1367-1378.doi: 10.16333/j.1001-6880.2025.7.018 cstr: 32307.14.1001-6880.2025.7.018

• 综述 • 上一篇    下一篇

丰城鸡血藤化学成分、药理作用研究进展及其质量标志物预测

何小燕1,金 晨2,张 凌1*   

  1. 1江西中医药大学药学院;2江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
  • 出版日期:2025-07-28 发布日期:2025-07-28
  • 基金资助:
    江西中医药大学博士启动基金(2022WBZR007);国家自然科学基金(81960697)

Research progress on chemical composition and pharmacological action of Millettia nitida Benth.var.hirsutissima Z.Wei and prediction analysis of its quality markers

HE Xiao-yan1,JIN Chen2,ZHANG Ling1*   

  1. 1School of Pharmacy,Jiangxi University of Chinese Medicine;2Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China
  • Online:2025-07-28 Published:2025-07-28

摘要:

丰城鸡血藤作为一种藤茎类中药,广泛应用于活血化瘀,舒筋通络。其化学成分丰富多样,主要包括黄酮类、三萜及甾体类、木脂素类、酚酸类等成分,具有调节血液系统、抗肿瘤、抗氧化、抗炎等药理作用。通过对丰城鸡血藤化学成分和药理作用进行综述,基于中药药性、化学成分可测性、入血成分、药效、网络药理学、植物亲缘学及化学成分特有性对丰城鸡血藤的质量标志物(quality markers,Q-Marker)进行预测。初步预测木犀草素、大豆黄素、染料木素、刺芒柄花素、异甘草素、美皂异黄酮、山柰素、丰城鸡血藤异黄酮苷F等可作为丰城鸡血藤的主要Q-Marker,为丰城鸡血藤的质量评价提供科学依据。

关键词: 丰城鸡血藤, 化学成分, 药理作用, 质量标志物, 木犀草素, 刺芒柄花素

Abstract:

Millettia nitida Benth. var. hirsutissima Z. Wei, as a type of vine like traditional Chinese medicine, is widely used in promoting blood circulation and removing blood stasis, as well as relaxing tendons and unblocking collaterals. Its chemical composition is rich and diverse, mainly including flavonoids, triterpenes and steroids, lignans, phenolic acids and other components, which have pharmacological effects such as regulating the blood system, anti-tumor, antioxidant, anti-inflammatory, etc. By reviewing the chemical components and pharmacological effects of M. nitida var. hirsutissima, the quality markers (Q-Marker) of M. nitida var. hirsutissima were predicted based on the properties of traditional Chinese medicine, the measurability of chemical components, blood components, pharmacological effects, network pharmacology, plant genealogy and chemical ingredient endemism. Preliminary predictions indicated that luteolin, daidzein, genistein, formononetin, isoliquiritigenin,biochanin A, kaempferol, and hirsutissimiside F could be used as the main Q-Marker for the quality evaluation of M. nitida var. hirsutissima.

Key words: M. nitida var. hirsutissima; chemical components, pharmacological effects, quality markers, luteolin; formononetin

中图分类号:  R284.1 R285