Alternaria sp. is one of the most common fungi in nature, with a wide variety of species and wide distribution. As pathogenic fungi, Alternaria not only cause serious economic losses but also have adverse effects on human health. However, its strong secondary metabolic capacity can produce metabolites with activities such as insect resistance, antibacterial and anti-tumor. Some products can even control weed and inhibit the growth of marine plankton. So the secondary metabolites of Alternaria have great potential research and development value. This article summarizes 128 secondary metabolites produced by Alternaria from 2013 to 2023 that can be further developed and utilized, and systematically summarizes the chemical structures and biological activities of all metabolites, in order to provide scientific basis for further development and utilization of secondary metabolites of Alternaria.