Abstract: The aim of this study was to investigate the effects of Protohermes grandis extract on the growth and reproduction of mice.Different concentrations (0.625%,1.250% and 2.500%) of P.grandis extracts were investigated.The results showed that there were no significant effects of P.grandis extracts on the mice’s growth;The first littering time of P.grandis extract group was shorten;The litter size,ovary’s index and the survival rate of F2 before weaning and the sperm density of P.grandis extract group were increased significantly.This study demonstrated that P.grandis extracts can promote mice’s reproductive performance.In addition,mice’s reproduction was improved significantly by 0.625% of P.grandis extract,while it was inhibited by 2.500% of P.grandis extract.

Key words: Protohermes grandis, mice, body weight, litter size, reproduction, sperm