NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (4): 592-597. doi: 10.16333/j.1001-6880.2015.04.007

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Experimental Study on Antihypertensive Effects and Mechanisms of Total Flavonoids of Flos Chrysanthemi on Spontaneous Hypertension Rats

ZHANG Liu-ji1,2*, ZHANG Hai-bo1, TU Wan-qian2, ZHOU Li1, YANG Ming-jie1   

  1. 1 School of Medicine,Henan university of Traditional Chinese Medicine,Zhengzhou 450008,China; 2 Henan Academy of Traditional Chinese Medicine,Zhengzhou 450004,China
  • Online:2015-04-28 Published:2015-05-08

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Abstract: To study the antihypertensive effects and mechanisms of total flavonoids of Flos Chrysanthemi (TFFC) on spontaneous hypertension rats (SHR).The SHR were randomized into 5 groups:model group,high-dose,middle-dose,low-dose group of TFFC and enalapril group.Blood pressure and heart rate were measured by Non-Invasive Blood Pressure Analyzer,the contents of plasma endothelin (ET),angiotensinⅡ (AngⅡ),aldosterone (ALD) and plasma renin activity (PRA) were determined by radio-immunity method.The results showed that TFFC can decrease blood pressure (P<0.01) and heart rate (P<0.05),decrease the contents of plasma ET (P<0.05),AngⅡ (P<0.01),ALD (P<0.01) and PRA (P<0.01).The antihypertensive effect of TFFC was possibly caused by improving the endothelial function and inhibiting the activity of renin-angiotensin-aldosterone system (RAAS).

Key words: total flavonoids of Flos Chrysanthemi, SHR, blood pressure, ET, AngⅡ, ALD, PRA

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