Abstract: Deep-sea environmentis complex and diverse,in which microorganism can produce novel bioactive and structure secondary metabolites through their unique metabolic pathways to adapt this extreme environment.Fungi are one of the important microbial components in the deep sea,which have attracted considerable attention in recent years,as their metabolites are novel compounds high-producing and possess interesting biological activities.This review highlighted 217 new secondary metabolites produced by fungi from the deep sea (>50 m) during 2004-2017.These fungi distributed mainly in Penicillium(30%),Aspergillus(24%),Spiromastix(13%) and Acremonium(7%) of 18 genera.Their structures contained polypeptides (99),alkaloids (54),terpenes (50),peptides (11),etc.Their cytotoxic,antimicrobial,antiviral and antifouling activities have been comprehensively investigated.

Key words: deep-sea, fungi, secondary metabolites, structure, activity