Abstract: The steady state regulation of glycolipid metabolism is the basis of maintaining the basic life activities of the body.The disorder of glycolipid metabolism is closely related to the occurrence and development of diabetes mellitus,obesity,fatty liver,cardiovascular disease and abnormal cell proliferation.Fish oil,enriched in bioactive n-3 polyunsaturated fatty acids,has therapeutic value for the treatment of glucose metabolism and lipid metabolism disorders.But the role of n-3 polyunsaturated fatty acids is complex and multifaceted,and the current understanding of its cellular targets and molecular mechanism of action is still incomplete.This review discusses recent evidence on how n-3 polyunsaturated fatty acids modify the glucose and lipid metabolism.

Key words: polyunsaturated fatty acids, glucose metabolism, lipid metabolism, gut microbiota, nervous system