Liver disease,a serious threat to human health,has attracted considerable attention worldwide.Liver fibrosis represents a common pathological process of various chronic liver diseases,with a complex pathogenesis involving multiple aspects such as intrahepatic lipid metabolism disorders,persistent inflammatory responses,and oxidative stress.Recent researches have shown that mitochondrial dysfunction can lead to excessive lipids accumulation and hepatic steatosis,which thereby contributes to liver injury,hepatitis,and even liver fibrosis.Consequently,the regulation of mitochondrial function and lipid metabolism has emerged as a promising new direction for drug development against liver fibrosis.Chinese medicine boasts a long history of application and has notable advantages in treating liver fibrosis.A variety of Chinese herbal formulas,single herbs,and isolated compounds have been proven to regulate mitochondrial function and lipid metabolism,ameliorate hepatocyte damage and inflammation,and alleviate the progression of liver fibrosis.This review will elaborate on the relationship of mitochondrial function,lipid metabolism,and hepatic fibrosis,as well as the related pharmacological role and mechanism of Chinese medicine in the intervention of liver fibrosis,which will provide a valuable insight for the effective prevention and control of liver fibrosis.