NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2026, Vol. 38 ›› Issue (7): 1595-1605. doi: 10.16333/j.1001-6880.2026.7.021 cstr: 32307.14.1001-6880.2026.7.021

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Research progress on triterpenoids in improving diabetic complications

SONG Li-zhen1,2,LUO Ya-ping1,2,LIU Xing-qing2,DONG Qi2*   

  1. 1School of Pharmacy,Qinghai University,Xining 810016,China;2Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008,China
  • Online:2026-07-24 Published:2026-07-23

Abstract:

Diabetic complications are important causes of disability and death in patients.Although current clinical treatments can delay disease progression,problems such as adverse reactions associated with long-term medication and single therapeutic targets still limit their preventive and therapeutic effects.Triterpenoids have exhibited promising application potential in ameliorating diabetic complications due to their characteristics of multi-target regulation.On the basis of briefly summarizing the basic structural features of triterpenoids,this paper focuses on investigating their specific applications in diabetic nephropathy,neuropathy,retinopathy and cardiovascular diseases.It elaborates on the research progress of triterpenoids in intervening in diabetic complications through multiple mechanisms,including improving glycolipid metabolic disorders and insulin resistance,and alleviating hyperglycemia-induced oxidative stress and inflammatory responses.Meanwhile,this paper collates relevant research findings,discusses the limitations of existing studies,and prospects the future development of triterpenoids in this field,thereby providing valuable references for further research and clinical applications.

Key words: triterpenoids, diabetes, diabetic complications, oxidative stress, inflammatory response

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