天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (6): 986-989.doi: 10.16333/j.1001-6880.2015.06.008

• 研究论文 • 上一篇    下一篇

蛇床子素对离体肺动脉环的作用

何观虹,滕振霞,姚丽*   

  1. 哈尔滨医科大学药学院生药学教研室,哈尔滨 150081
  • 出版日期:2015-06-30 发布日期:2015-07-10

Effect of Osthole on Isolated Pulmonary Arteries

HE Guan-hong,TENG Zhen-xia,YAO Li*   

  1. Department of Pharmacognosy,College of Pharmacy,Harbin Medical University,Harbin 150081,China
  • Online:2015-06-30 Published:2015-07-10

摘要: 为了研究蛇床子素对离体肺动脉的作用,本研究游离人及健康SD大鼠的肺动脉血管和SD大鼠的肠系膜动脉血管,剪成长约3 mm的血管环,观察不同浓度的蛇床子素对人和大鼠离体肺动脉以及大鼠肠系膜动脉收缩的作用。结果表明蛇床子素(109~105 mol/L)对人和大鼠苯肾上腺素预收缩的肺动脉具有浓度依赖性的舒张作用,对大鼠肠系膜动脉和正常的肺动脉无舒张作用。证实蛇床子素可舒张人和大鼠离体肺动脉环,其舒张作用具有浓度依赖性和组织特异性。

关键词: 蛇床子素, 肺动脉高压, 肺动脉环

Abstract: To study the effect of osthole on isolated pulmonary arteries by using force-electricity transducers,pulmonary arteries isolated from human beings and healthy SD rats and mesenteric arteries from SD rats were cut into rings (about 3 mm in length) and observed the response of artery contraction to different doses of osthole. The results showed that osthole (109-105 mol/L) relaxed phenylephrine precontrated isolated pulmonary arteries of both human beings and rats in a dose-dependent manner,but not mesenteric arteries and normal pulmonary arteries.Therefore,osthole relaxed human and rat isolated pulmonary arteries in a dose-dependent manner and was tissue specific.

Key words: osthole, pulmonary arterial hypertension, pulmonary arterial rings

中图分类号: 

R93