天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (1): 156-163.doi: 10.16333/j.1001-6880.2016.01.027

• 综述 • 上一篇    下一篇

皂苷体外生物转化水解反应的研究进展

穆丽华1,刘屏1*,张静2   

  1. 1 中国人民解放军总医院临床药理研究室,北京 100853;2 山西中医学院中药学院,太原 030024
  • 出版日期:2016-01-29 发布日期:2016-02-01

Review on Hydrolysis Biotranformation Studies of Triterpenoid Saponins

MU Li-hua1,LIU Ping1*,ZHANG Jing2   

  1. 1 Department of Clinical Pharmacology,General Hospital of PLA,Beijing 100853,China; 2 Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China
  • Online:2016-01-29 Published:2016-02-01

摘要: 皂苷(Saponin)是苷元为三萜或螺旋甾烷类的一类较复杂的糖苷类化合物。皂苷分子中糖链的结构与其生物活性密切相关,皂苷中糖链结构的复杂性给糖基的选择性水解研究带来了许多困难。生物转化是利用各种酶体系对天然活性化合物进行合成与结构修饰。利用生物转化技术能对皂苷完成一些有机合成难以进行的水解反应,得到更具新药开发价值的目标化合物。本文综述近几年微生物和游离酶转化技术对皂苷水解反应的研究进展,为皂苷生物转化研究的发展提供方向。

关键词: 生物转化, 水解反应, 皂苷, 微生物,

Abstract: Saponin is a kind of complex compounds with triterpenoid or spiral aglycones and sugar chains.The biological activities of saponins are closely related to their sugar chains and it is difficult to selectively hydrolysis the sugar chains by chemical methods.Biotransformations are chemical reactions catalyzed by cells,organs or enzymes,and may be used for specific conversions of complex substrates.Some leading compounds which are difficult to be synthesized by organic hydrolysis can be obtained using biotransformation technology.In order to provide a basic view on the development of biological transformation of saponins,this article reviewed the hydrolysis biotransformation of saponins reported in recent years.

Key words: biotransformation, hydrolysis, saponins, microorganism, enzyme

中图分类号: 

R932