天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (9): 1372-1376.doi: 10.16333/j.1001-6880.2016.9.006

• 研究论文 • 上一篇    下一篇

四齿四棱草的抗炎镇痛作用及免疫调节活性研究

欧阳凯1，何先元1*，周卯勤2，冯沼润1，黄英如1，程鹏3   

  1. 1 重庆医科大学中医药学院，重庆 400016；2 重庆市药物种植研究所，重庆 408435；3 重庆医科大学实验管理中心，重庆 400016
  • 出版日期:2016-09-30 发布日期:2017-03-24

Anti-inflammatory,Analgesic and Immunomodulatory Effects of Schnabelia tetradonta

OUYANG Kai1,HE Xian-yuan1*,ZHOU Mao-qin2,FENG Zhao-run1,HUANG Ying-ru1,CHENG Peng3   

  1. 1 College of Traditional Chinese Medicine,Chongqing Medical University,Chongqing 400016,China;2 Chongqing Institute of Medicinal Plant Cultivation,Chongqing 408435,China; 3Experimental management center of Chongqing Medicinal University,Chongqing 400016,China
  • Online:2016-09-30 Published:2017-03-24

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摘要： 研究四齿四棱草的抗炎镇痛作用及免疫调节活性。采用热板法，评价镇痛效果。采用耳肿胀法、腹膜炎、气囊炎同时测定气囊灌洗液的总蛋白、SOD、NO及血清中MDA、PGE-2水平，测定耳肿胀、气囊炎小鼠的胸腺指数和脾指数，初步分析四齿四棱草可能的抗炎镇痛机制及免疫调节活性。结果表明，四齿四棱草能显著抑制小鼠腹腔毛细血管通透性，降低小鼠气囊灌洗液中的蛋白量和NO量，降低气囊炎小鼠血清中的PGE-2和MDA水平，增强SOD活性；中、低剂量能提高小鼠的痛阈，抑制二甲苯致小鼠耳肿胀，可显著提高脾指数（P<0.05或P<0.01）。因此，四齿四棱草具有抗炎镇痛及免疫调节活性。

关键词: 四齿四棱草, 镇痛, 抗炎, 免疫调节

Abstract: To study anti-inflammatory,analgesic and immunomodulatory effects of Schnabelia tetradonta. The analgesic effect was assessed by hot-plate test.The anti-inflammatory effect were observed by ear edema,peritonitis,air-pouch tests.The effects on the total protein (TP),superoxide dismutase (SOD),nitric oxide (NO),the content of malondialdehyde (MDA),and prostaglandin (PGE-2) level in blood serum were determined,and the immune organ index of ear edema and air-pouch of mice were investigated.The results showed that S.tetradonta produced significantly inhibitory effects on permeability and reduced the total protein content,decreased the levels of NO,PGE-2 and MDA,increased the activities of SOD.Middle-dose and low-dose of S.tetradonta can enhance the pain threshold of mice,inhibit the ear edema,significantly increased the spleen index (P<0.05 or P<0.01).Hence, S.tetradonta had analgesic,anti-inflammatory and immunomodulatory effects.

Key words: Schnabelia tetradonta (Sun) C.Y.Wu et C.Chen, analgesia, anti-inflammation, immunomodulation

中图分类号: 

R285.5

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