关键词: 川黄柏, 化学成分, 果实, 结构鉴定

Abstract: Ten compounds were obtained from the ethanol extract of the fruits of Phellodendron chinense Schneid by applying various chromatographic techniques.Their structures were elucidated and identified as 23-aldehyde-tirucall-7-ene-3-one (1),(23R,24S)-21-oxomelianodiol (2),3β,22S-dihydroxy-tirucalla-7,24-dien-23one (3),21,23-lactone-24,25 dihydroxy-tirucall-7-ene-3-one (4),Aphagranins F (5),24,25-epoxy-tirucall-7-ene-3,23-dione(6),Friedelin (7),Rutaecarpine (8),(2E,4E,8Z)-N-isobutyl tetradecatrienamide (9),7-Demethylsuberosin (10) respectively,based on the spectral data.Among them,compound1 were new natural products,2-5,7 were obtained from the fruits of P.chinense for the first time.Compound 3 and 5can inhibit the proliferation of MDA and K562 cells,respectively,their IC₅₀ were 7.38 (± 3.24) μmol/L,3.86 (± 2.71) μmol/L,accordingly.

Key words: Phellodendronchinense Schneid, chemical constituents, fruits, structural elucidation