To reveal the antidepressant effect and components of the fiber roots of Cyperus esculentus L.(FRCEL) oleoresinn.Ultra-performance liquid chromatography coupled with quadruple time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was used to analyze the chemical composition of FRCEL oleoresin.The mouse model of chronic unpredictable mild stress (CUMS) depression was established,the antidepressant effect of FRCEL oleoresin was investigated from the aspects of animal behaviors,changes of neurotransmitter content and hippocampal histopathology.it can be concluded that FRCEL oleoresin contained ketones (68.891%),esters (8.787%),alcohols (4.258%),alkenes (0.374%) and other substances (12.879%),and the main components are α-cyperone (59.536%) and germacrone (5.875%).After CUMS model mice were administered,FRCEL oleoresin significantly shortened the rest time of forced swimming and tail suspension.The total distance,average speed and duration of the center were significantly increased.The content of 5-hydroxytryptamine(5-HT) and norepinephrine(NE) in the serum of mice were significantly increased in the high-dose FRCEL oleoresin group.The hippocampal cells of mice in the high-dose FRCEL oleoresin group were arranged neatly,and the cell membrane of neurons was basically intact.FRCEL oleoresin may improve depression-like behavior by regulating the expression of 5-HT and NE in the serum of CUMS depression model mice,repairing the damage of hippocampus in mice.

"> oleoresin from fiber roots of Cyperus esculentus L., constituents analysis, chronic unpredictable mild stress model, antidepressant effect