关键词: 青藤碱, 系膜增生性肾小球肾炎, 细胞间粘附分子-1

Abstract:

To explore affection of Sinomenine (SIN) on the kidney pathology and Intercellular cell adhesion molecule-1 (ICAM-1) expression in rats with mesangial proliferative glomerulonephritis (MsPGN).The test uses the improvement chronic serum sickness nature MsPGN model,with the light mirror observing mesangial region and kidney tubules-mesenchyma,using immunohistochemical method observe the expression of ICAM-1,at the same time,carries on the semi-definite quantity analysis with the pathology image analysis system.The results showed that compared with the normal group,mesangial matrix index (%) remarkably heighten (P<0.01) and capillary lumen diameter (μm) obviously reduce.Compard with the model group,in SIN group,mesangial matrix index（%）remarkably reduce (P<0.01) and capillary lumen diameter (μm) obviously improve (P<0.01).In the nephridial tissue immunohistochemistry result showed that SIN can obviously reduce Relative amount (%) and Density expression (P<0.01).Comparing between two treatments groups,although the result of SIN group is lower than TWP group but the two comparison have no the remarkable difference (P>0.05).This result suggested that SIN can effectively reduce the kidney pathological lesion,refrain the expression of ICAM-1.