HPLC fingerprint of Hedysari Radix and its different processed products (Hedysari Radix processed by pharmacopoeia method and Hedysari Radix processed with honey chaff) and multi-component determination method were established to evaluate the quality of Hedysari Radix and different prepared products comprehensively. HPLC method was used to establish fingerprints of different Hedysari Radix processed products, and the contents of five main components were determined. principal component analysis was performed. PCA), orthogonal partial least squares discrimination analysis (OPLS-DA) and other methods were used to analyze the results, and the weights of indicators were calculated according to the grey relational degree analysis theory. The technique for order preference by similarity to ideal solution (TOPSIS) was established to evaluate the quality of Hedysari Radix and its different processed products. The results showed that there were 22 common peaks in the fingerprints of different Hedysari Radix processed products, and five common peaks were identified, which were vanilic acid (peak 5), calycosin-7-O-β-D-glucoside (peak 8), ononin (peak 12), calycosin (peak 17) and ononin (peak 18). A total of five principal components were extracted from PCA, and 15 batches of honey bran and Hedysari Radix were ranked first in the comprehensive score. The results of weighted TOPSIS model showed that the relative proximity values of 15 batches of different prepared Hedysari Radix were 0.116 1-0.447 3, 0.238 3-0.501 1, and 0.318 9-0.654 2, respectively. The HPLC fingerprint and multi-component content determination method established in this study is simple, stable and reliable, and the weighted TOPSIS algorithm model is reasonable, which can be used for comprehensive quality evaluation of Hedysari Radix and its different processed products.