天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (4): 486-489.doi: 10.16333/j.1001-6880.2016.4.003

• 研究论文 • 上一篇    下一篇

Cladosperanol A,海洋真菌Cladosporium perangustum FS62中一个新的二聚萘满酮

范震1,2,3,孙章华2,陈玉婵2,李浩华2,章卫民2*   

  1. 1 中国科学院南海海洋研究所,广州 510301;2 广东省微生物研究所 省部共建华南应用微生物国家重点实验室 广东省菌种保藏与应用重点实验室 广东省微生物应用新技术公共实验室,广州 510070;3 中国科学院大学,北京 100049
  • 出版日期:2016-04-30 发布日期:2016-05-13

Cladosperanol A,a New Dimeric Tetralone from Marine-derived Fungus Cladosporium perangustum FS62

FAN Zhen1,2,3,SUN Zhang-hua2,CHEN Yu-chan2,LI Hao-hua2,ZHANG Wei-min2*   

  1. 1 South China Sea Insititute of Oceanology Chinese Academy of Sciences ,Guangzhou 510006,China; 2 State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology,Guangdong Institute of Microbiology,Guangzhou 510070,China; 3 University of Chinese Academy of Sciences,Beijing 100049,China
  • Online:2016-04-30 Published:2016-05-13

摘要: 采用硅胶柱、凝胶柱、HPLC等色谱技术从海洋真菌Cladosporium perangustum FS62的发酵液提取物中分离得到了1个化合物(1),通过波谱数据分析(HR-ESI-MS、1D NMR、2D NMR、CD)确定该化合物为1个新的二聚萘满酮,结构为(4S,4′S)-4,8,8′-trihydroxy-2,3,2′,3′-tetrahydro-[4′,5-binaphthalene]-1,1′-(4H,4′H)-dione,命名为cladosperanol A。

关键词: cladosperanol A, 二聚萘满酮, 次级代谢产物, Cladosporium perangustum, 海洋真菌

Abstract: A new compound (1) was isolated from the fermentation broth extract of marine fungal strain Cladosporium perangustum FS62 by various chromatographic methods such as silica gel,reverse silica gel,Sephadex LH20,HPLC, etc. On the basis of detailed spectroscopic analysis (HR-ESI-MS,1D NMR,2D NMR,CD),1 was elucidated as a new dimeric tetralone with the structure of (4S,4′S)-4,8,8(trihydroxy-2,3,2′,3′- tetrahydro-[4′,5-binaphthalene]-1,1′(4H,4′H)-dione,named as cladosperanol A.

Key words: cladosperanol A, dimeric tetralone, secondary metabolite, Cladosporium perangustum, marine-derived fungus

中图分类号: 

R284.2