This study aims to optimize the integration of fresh processing and processing of Citri Sarcodactylis Fructus (CSF) silk by analytic hierarchy process (AHP)-criteria importance through inter-criteria correlation (CRITIC) combined with the Box-Behnken response surface method.Considering the comprehensive score as the evaluation indicator,the center points of four influencing factors were selected after conducting the single factor experiment.Based on the single factor experiment,the response surface method was designed to optimize the best integration of fresh processing and processing by taking the comprehensive score of the hesperidin,diosmin,5,7-dimethoxycoumarin,water-soluble extract,and alcohol-soluble extract.Based on the above results,three batches of samples were used to validate the optimal process.At the same time,the best integration of fresh processing and processing of CSF silk was compared with the traditional process in terms of the appearance and content of the index components.The best integration of fresh processing and processing of CSF silk was finally obtained as follows:slice thickness of 4 mm,dried until the moisture content was 70%,then removed and cut 5 mm wide silk,and dried at 57 ℃ until the constant weight.The experimental results showed that the best integration of fresh processing and processing of CSF silk was stable and feasible,and compared with the traditional processing,the appearance and the contents of the index components obtained by this process were better,which can provide feasible suggestions for the production of CSF silk decoction pieces.