Abstract: To study the effect of peanut skin extracts on vascular rings and heart.The perfusion model of thoracic aorta rings of rats and isolated frog heart were applied to observe the response of artery contraction of peanut skin extract and its active ingredient.High performance liquid chromatography (HPLC) was used to analyze and determine the active ingredient.The result showed that peanut skin extract can significantly relax the contraction of rat aortic ring induced by HCL and NE,and significantly reduce the heart rate and mean tension of frog isolated heart.The HPLC analysis results showed that resveratrol was one of the effective ingredients of peanut skin extract,which was consistent with the effect of peanut extract.In conclusion,peanut skin extract can significantly relax rat aortic ring,reduce the heart rate and mean tension of frog isolated heart.Peanut skin had the effect of vasorelaxation and heat protection.Its effective ingredient was resveratrol.

Key words: peanut skin, isolated vascular rings, isolated, resveratrol