NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (12): 2175-2179.doi: 10.16333/j.1001-6880.2018.12.022

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Anti-Osteoporosis Effects Induced by Retinoic Acid in Mice of Hexane Extract from Raw and Processed Polygonum multiflorum

WU Xiao-qing1, CHEN Xiao-zhen2*, LIU Rui-ying1, REN Yao-yao1, JIANG He-zhong1, TAN Rui1*   

  1. 1College of life science and Engineering,Southwest Jiao Tong University ,Chengdu 610031,China; 2Institute of Biology,Chinese Academy of Sciences,Chengdu,610041,China
  • Online:2019-01-02 Published:2019-01-02

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Abstract: We investigated the anti-osteoporosis effect and the possible mechanism of PM-HE (Hexane extract from Raw and Processed Polygonum multiflorum) in animal model.Kunming mice were randomly divided into 9 groups:Control group (normal saline),model group,nilestriol group (2 mg/kg),PM-HE groups (48,24 mg/kg).The mice osteoporosis was induced by given retinoic acid intragastrically.After oral administration for 14 days,the features of bones and biochemicals in serum were determined to evaluate the anti-osteoporosis effects of PM-HE .The results showed:PM-HE can induce high conversion of osteoporosis.The levels of ALP,TRAP and BGP in the PM-HE groups were lower than those in the model group (P<0.05,P<0.01),whereas the E2 level was higher than that of the model group (P<0.05).PM-HE can prevent the loss bone in the experimental mice.The mechanism may be the inhibition of estrogen decrease and the high bone turnover.

Key words: raw Polygonum multiflorum Thunb, processed Polygonum multiflorum, retinoic acid, anti-osteoporosis

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