Abstract: In order to research the optimal extraction process of total flavoniods and total saponins from Abrus cantoniensis Hance.Properties of DESs (including type,component mole ratio and water content),extraction temperature,extraction time,and liquid-solid ratio were studied by using single factor experiment and Box-Behnken experimental design combined with responsesurface methodology(BBD-RSM).The results indicated that the optimal extraction conditions for total flavoniods were as follows:ChCl/ethylene glycol with mole ratio of 1∶2 and water content of 30% as solvent,extraction temperature of 80 ℃,extraction time of 40 min,and liquid-solid ratio of 15∶1 (mL/g).The optimum conditions for total saponins were as follows:ChCl/lactic acid with mole ratio of 1∶4 and water content of 25% as solvent,extraction temperature of 80 ℃,extraction time of 64 min,liquid-solid ratio of 56∶1 (mL/g).Under the optimum conditions,the extraction yields of total flavoniods and total saponins increased by 33.3% and 96.4%,respectively,compared with conventional extraction solvents.The research could provide a new idea for efficient and safe extraction of flavoniods and saponins from Abrus cantoniensis Hance.

Key words: DESs, Abrus cantoniensis Hance, BBD-RSM, total