Abstract: To investigate the mechanism of Qiliqiangxin capsule in the treatment of myocardial infarction based on network pharmacology.TCMSP database and Pubmed was applied to screening active components and potential targets of the 11 traditional Chinese medicines.The myocardial infarction(MI)-related targets were collected from Genecards and OMIM database.Drug-component-target-disease network diagram was construbted by Cytoscape software.STRING database was used to draw PPI network.The gene ontology (GO) and KEGG pathway enrichment analysis were conducted for key targets..There are 106 active ingredients in Qiliqiangxin capsule,including quercetin,kaferferol and calycosin,which may regulate 173 signaling pathways including TNF,il-17 and Th17 cell differentiation and Apoptosis by targeting 188 target proteins such as STAT3,AKT1 and IL6.In conclusion,the pharmacological mechanism of Qiliqiangxin capsule in the treatment of myocardial infarction may be multi-components,multi-targets,multi-pathways and multi-level.This study will provide theoretical basis for Qiliqiangxin to treat myocardial infarction.

Key words: Qiliqiangxin capsule, myocardial infarction, network pharmacology, mechanism