Synthesis and Antitumor Activity of Cyclopamine Analogues

doi:10.16333/j.1001-6880.2015.05.027

Abstract

Abstract: Cyclopamine is a steroid alkaloid with Hedgehog signal pathway inhibitory activity and exhibits significant antitumoractivity.In this study,cyclopamine analogues were synthesized by reduction,oxidation and methylation from an available alkaloid,jervine.The structures of the yielded compounds were determined by MS,1D and 2D NMR.Structures of compounds 4,9 and 10 have not been reported previously.The antitumor activities of the 10 synthesized compounds against Aspc-1 and SGC-7901 cancer cells were evaluated by MTT method.

Key words: jervine, reduction, Aspc-1, SGC-7901, MTT method

CLC Number:

R931.6

ZHENG Xiao-hong, GUAN Tong-wei, HAN Xu-ran, WANG Shi-sheng*, ZHAO Wei-jie. Synthesis and Antitumor Activity of Cyclopamine Analogues[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(5): 890-895.

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Synthesis and Antitumor Activity of Cyclopamine Analogues

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