NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2021, Vol. 33 ›› Issue (3): 419-425.doi: 10.16333/j.1001-6880.2021.3.009

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Diterpenoid alkaloids from the roots of Aconitum forrestii Stapf

LIU Wei,REN Jia-li,LI Xin-yu,CHEN Lin,HUANG Shuai*   

  1. School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China

  • Online:2021-03-28 Published:2021-04-01

Abstract:

To find new compounds in Aconitum forrestii Stapf and enrich the diversity of chemical composition.A new diterpenoid alkaloid along with thirteen known diterpenoid alkaloids were isolated from the ethanol extract of the roots of A. forrestii by silica gel column chromatography.Their structures were identified as 8-O-methyl-14-O-anisoylchasmanine (1),14-acetoxy-8-O-methylsachaconitine (2),14-acetyltalatizamine (3),talatisamine (4),chasmanine (5),ezochasmanine (6),crassicautine (7),geniculatine C (8),cammaconine (9),vilmoraconitine (10),aconitramine A (11),vilmorrianine G (12),hemsleyaconitine G (13) and heterophylloidine (14) by means of spectroscopic methods such as HR-ESI-MS,1D and 2D NMR.The protective activity against adriamycin induced H9c2 myocardial cell injury of all compounds have been investigated,and the results showed that compounds 3,10,11 and 12 had a certain protective effect.

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