Abstract: Eupenicillium fungi,which has 62 species,is one of the important branches of teleomorphic Penicillium.  It was found that the secondary metabolites of this fungus were diverse and rich in chemical diversity.This paper reviewed the sources,chemical structures and bioactivites of all the 66 important natural products of Eupenicillium fungal origins from 1974 to 2016 and 50% of the 66 important natural products displayed bioactivities such as cytotoxicity,antibacterial activity,antioxidant and antiinsectanactivity,which are very valuable for further research and may be identified as potential lead compounds for drug development.

Key words: Eupenicillium sp., secondary metabolite, chemical constituent, bioactivity