天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (4): 555-561.doi: 10.16333/j.1001-6880.2024.4.001

• 研究论文 •    下一篇

乌药中3个新的倍半萜

李业生,白旭岚,许红涛*,侴桂新*   

  1. 上海中医药大学中药研究所,上海 201203
  • 出版日期:2024-04-28 发布日期:2024-04-28
  • 基金资助:
    重大新药创制科技重大专项子课题(2019ZX09735002-004)

Three new sesquiterpenoids from Linderae Radix

LI Ye-sheng,BAI Xu-lan,XU Hong-tao*,CHOU Gui-xin*   

  1. Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
  • Online:2024-04-28 Published:2024-04-28

摘要: 研究乌药的化学成分。采用硅胶、ODS、Sephadex LH-20、制备液相等多种色谱分离技术进行分离纯化,通过波谱数据分析进行结构鉴定。从乌药90%乙醇提取物中分离得到4个倍半萜,分别鉴定为linderaggredin B1(1)、乌药酮酸A(2)、乌药酮酸B(3)、chlorahupetolide K(4),其中化合物1~3为新化合物,化合物4为首次从樟科中分离得到。

关键词: 乌药, 化学成分, 倍半萜, 桉叶烷型, 钓樟烷型

Abstract:

To study the chemical constituents of Linderae Radix,three new compounds,named linderaggredin B1 (1),lindenonic acid A (2),and lindenonic acid B (3),along with one know compound chlorahupetolide K (4) were isolated from the 90% EtOH extract of Linderae Radix by various chromatographic techniques such as silica gel,ODS,Sephadex-LH 20,Pre-HPLC,their structures was elucidated by spectral data analysis.Compound 4 was isolated from Lauraceae plants for the first time.

Key words: Linderae Radix, chemical constituents, sesquiterpenoids, eudesmane-type, lindenane-type

中图分类号:  R284.1 R284.2