Abstract: Novel MMIPs were designed and synthesized by surface-suspension polymerization using ethylene glycol maleic rosinate acrylate (EGMRA) as the cross-linking agent in this study. First,oleic acid (OA) was modified onto the surface of Fe₃O₄ NPs that were prepared by the co-precipitation. Finally,the MMIP was prepared by suspension polymerization using Fe₃O₄ NPs@OA as magnetic core,MNZ as the template molecule,methacrylic acid as the functional monomer,and modified rosin as the cross-linking agent. The optimal synthetic conditions were studied by single factor experiment. The morphology,magnetic,thermal stabilization and adsorption selectivity properties of the obtained MMIPs were characterized by fieldemission scanning electron microscope (SEM),Fourier transform infrared spectrometer (FT-IR),vibrating sample magnetometer (VSM),thermal gravimetric analyzer (TGA) and re-binding experiments. The results indicated that the MMIPs materials had uniformity particle,stronger thermal stabilization,fast magnetism response and high selective adsorption capacity. The absorbed analytes of MMIPs were quickly separated using an external magnetic field which greatly improved sample pre-treatment efficiency. The MMIPs can be used for the separation and enrichment of trace amounts of MNZ in cosmetic samples.

Key words: metronidazole, magnetic molecularly imprinted polymers, solid-phase extraction, modified rosin