NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (增刊1): 186-189.doi: 10.16333/j.1001-6880.2017.S.037

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Neuroprotective Effect on Focal Cerebral Ischemia in Rats Treatment with the Inclusion Complex of C-21 Steroid Caudatin and Hydroxypropyl-β-Cyclodextrin

XIE Kai-qiang1,2,HUANG Lie-jun2,ZHANG Lei3,YUAN Chun-mao2,GU Wei2,FENG Lin-yin3*,HAO Xiao-jiang1,2*   

  1. 1 College of pharmacy,Guizhou University,Guiyang 550025,China;2The key laboratory  of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,Guiyang 550007,China;3Shanghai Institute of MateriaMedica,Chinese Academy of Sciences,Shanghai 201203,China
  • Online:2017-08-02 Published:2017-08-02

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Abstract: There has been few report regarding on neuroprotective effect of C21pregnane steroids and saponins on focal cerebral ischemia in rats.This study investigated the neuroprotective effect of the inclusion complex of caudatin and hydroxypropylβcyclodextrin on focal cerebral ischemia in brain injury rats,and the results indicated caudatin has moderately neuroprotective effect in a dose dependent manner.

Key words: Caudatin, focal cerebral ischemia in rats, neuroprotective effect