Abstract: To investigate the effects of volatile oil of Forsythia suspense (VOFF) on different rat models,and explore the mechanism of its anti-inflammatory and antipyretic effects.Two rat fever models were established by subcutaneously injection of dry yeast and intraperitoneal injection of lipopolysaccharide (LPS) to evaluate the antipyretic effect of VOFF,respectively.Rats cotton ball granuloma model,rats foot swelling model induced by subcutaneous injection of carrageen or fresh egg white at the right posterior foot were used to evaluate the anti-inflammatory effects.VOFF can significantly inhibit LPS and dry yeast induced fever,reduce carrageenan and fresh egg white induced rat paw edema,compared with the model group (P<0.05).It can also significantly inhibit the proliferation of granulation tissue,compared with the model group (P<0.01).The results showed that VOFF had obvious antipyretic and anti-inflammatory effects,which provided a theoretical basis for further research on heat clearing and detoxifying function.

Key words: volatile oil of Forsythia suspense, heat clearing and detoxifying, antipyretic, anti-inflammatory