NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2020, Vol. 32 ›› Issue (增刊1): 130-135.doi: 10.16333/j.1001-6880.2020.S.021

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Optimization of extraction of total flavonoids from Caragana korshinskii Kom.with ultrasound technology by response surface analysis

MA Yu-mei1,2,CHEN Tao1,YANG Xue1,2,SHEN Cheng1,2,YAN Shu-ping1,2,LI Yu-lin1*   

  1. 1Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810008,China;2 University of Chinese Academy of Sciences,Beijing 100049,China

  • Online:2020-06-28 Published:2020-07-21


In this paper,Caragana korshinskii in Qinghai region was taken as the research object.The total flavonoids in C. were extracted with the aid of ultrasound.On the basis of single factor experiments on extraction temperature,ethanol concentration,ultrasonic time and solid-liquid ratio,Box-behnken response surface method was used to optimize the extraction process of total flavonoids from C. korshinskii flowers.The results showed that the optimal extraction process for total flavonoids from C. korshinskii. flowers were as follows:extraction temperature 80 ℃,ethanol concentration 50%,ultrasonic time 60 min,and material-liquid ratio 1∶20.The optimized extraction process was used to perform three sets of verification experiments.The total flavonoid yield was 31.38 mg/g and the RSD was 0.17%.Box-Benhnken response surface method for the optimization of extraction of total flavonoids from C. korshinskii is stable and feasible.

Key words: Caragana korshinskii Kom. flowers., total flavonoids;response surface analysis;ultrasonic extraction

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