To explore the characteristics and rules of traditional Chinese medicine (TCM) in the treatment of diabetic cognitive dysfunction,and to provide new references for clinical medication.Methods:The Chinese Knowledge Network (CNKI),Wanfang Data (WF),Weipu Journal Full-text Database (VIP),China biology medicine disc(CBM),and Chinese Science Citation Database (CSCD) were retrieved from 1999 to October 2020 .The contained literature on the treatment of diabetic cognitive dysfunction with traditional Chinese medicine,after screening,establish a database,use Microsoft Excel 2019,SPSS Modeler 18.0,SPSS Statistics 25.0 software for data mining,and analyze the distribution and regularity of drug efficacy.Through searching TCMSP,OMIM,TTD,Pharm Gkb and Drugbank database to obtain the core drug combination and the effective active ingredients of the disease,using Cytoscape 3.8.0 software to construct the "compound-target" interaction network diagram,using Stitch and String to construct the protein-protein interaction (PPI) network,and use Cytoscape to perform network topology analysis to obtain the core target of drug and disease interaction.Screen the DAVID database for GO and KEGG enrichment analysis of core targets.Results:A total of 33 articles were included,123 Chinese medicine prescriptions,and 20 high-frequency Chinese medicines were obtained,including 26 pairs of core drug combinations such as Persicae Semen-Carthami Flos,Angelicae Sinensis Radix-Persicae Semen-Chuanxiong Rhizoma,Rehmanniae Radix Praeparata-Cuscutae Semen-Lycii Fructus,etc.There are 8 common factors and 6 categories of cluster analysis,109 active ingredients of the core formula,1 620 potential drug targets,1 490 potential disease gene targets,and the core formula treats diseases There are 76 core targets,involving 237 GO enrichment functions and 96 KEGG pathways.TCM treats diabetes cognitive dysfunction mainly by promoting blood circulation,removing blood stasis,nourishing qi and nourishing yin.The mechanism of its core drugs in the treatment of diabetic cognitive dysfunction may be related to insulin resistance,apoptosis,inflammation,endoplasmic reticulum stress is closely related.