Salt-fried Phellodendri Chinensis Cortex (SPCC) is a traditional Chinese medicine,22 batches of SPCC fingerprints were established,and four common components,3-O-ferulic acid,5-O-ferulic acid,berberine hydrochloride and phellodendrine hydrochloride,were identified.The analysis results of PCA and OPLS-DA showed that the differential component of different batches of SPCC was phellodendrine and berberine.Meanwhile,combined with the results of network pharmacological analysis,it was confirmed that berberine and phellodendrine were also the main active component of SPCC.Berberine and phellodendrine were the active components of SPCC which provided reference for the quality control of SPCC.