Nuclear magnetic resonance (NMR) technology has evolved into an indispensable tool for the structural identification of new compounds and the analysis of natural products.Because of its non-destructive and non-invasive characteristics,it is widely used in the field of pharmaceuticals,from the characterization of synthetic products to the determination of molecular structure and conformation of biological systems and the analysis of molecular interactions.NMR can provide rich and accurate structural information,such as Larmor frequency,chemical shift,spin-spin coupling,dipole coupling,relaxation time and other parameters,which is becoming the "gold standard" for structural analysis.The paper summarizes the application and research progress of NMR in drug discovery,drug interaction,drug metabolomics and solid-state NMR (ss NMR) in solid-state drug analysis.