To explore the material basis and medication rules of traditional Chinese medicine intervening in cytokine storm based on network pharmacology and data mining.With the help of GeneCards,DisGeNET,DrugBank,OMIM and other databases,the cytokine storm-related targets were precisely collected;the active ingredients and traditional Chinese medicine that might potentially intervene cytokine storm were screened and matched through TCMSP database;and Cytoscape 3.7.2 software was applied to construct target-compound,target-compound-traditional Chinese medicine network.Molecular docking between potential targets and candidate compounds was carried out by making use of the CB-Dock online molecular docking platform,and Ligplot software was used to display the combinations with better Affinity value.The related function of Microsoft Office Excel 2017 was utilized to calculate the nature,flavor and meridian of traditional Chinese medicine,while the network diagram of the nature and efficacy of traditional Chinese medicine was established at the same time.A total of 113 CS-related targets were retrieved,of which 35 target-matched compounds met the screening criteria,involving 49 candidate compounds.Through compound mapping,268 traditional Chinese medicine were finally matched,among which Ginkgo Folium,Patriniae Herba,Glycyrrhizae Radix et Rhizoma and Erigerontis Herba corresponed to more targets.This study demonstrated that the traditional Chinese medicine interfering with cytokine storms were mostly clearing away heat,promoting blood circulation and removing blood stasis.The taste of them was mainly bitter,while the nature was cold.This study systematically explores the material basis of traditional Chinese medicine intervening cytokine storm,summarizes the general medication laws of traditional Chinese medicine,and provides ideas for the future integration of traditional Chinese and western medicine interfering with cytokine storm and the development of related drugs.