This study aimed to investigate the chemical composition,antioxidant,enzyme inhibitory,and anti-inflammatory activities of Hedychium flavum flower extracts.H. flavum flower water extracts and ethanol extracts were obtained by reflux extraction method.The chemical composition of the extracts was identified by ultra-high-performance liquid chromatography coupled to quadrupole-orbitrap mass spectrometry (UHPLC-Q-Orbitrap-MS).A total of 58 compounds were identified,including 11 phenols and 18 flavonoids.The extracts showed strong antioxidant activity in the DPPH and ABTS assay and had certain inhibitory effects on α-glucosidase,tyrosinase,acetylcholinesterase,and butyrylcholinesterase.Within the non-toxic dose range (62.5,125,250 μg/mL),the extracts significantly reduced LPS-induced oversecretion of pro-inflammatory mediators (NO and PGE2) and cytokines (TNF-α,IL-6,IL-1β) in RAW 264.7 cells.Our study provides a theoretical basis for the development and utilization of H. flavum flower in the food,pharmaceutical,and cosmetic industries.