NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2024, Vol. 36 ›› Issue (2): 348-356. doi: 10.16333/j.1001-6880.2024.2.017

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Research status of kinsenoside

ZHANG Wen-ting1,YANG Min-jing2,MEI Yu1,WANG Ji-hua1*   

  1. 1Crop Research Institute,Guangdong Academy of Agriculture Sciences,Guangzhou 510640,China;2College of Agriculture and Biology,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,China
  • Online:2024-02-23 Published:2024-02-23

Abstract:

Kinsenoside,a bioactive glycoside component extracted from the medicinal plant Anoectochilus roxburghii,has been proven to have significant pharmacological effects.This review has collected relevant literature on kinsenoside,especially for the research results published in recent years.After sorting out and analyzing,the research status of kinsenoside is mainly divided into three parts,namely the basic information of kinsenoside,including chemical structure,source species and factors affecting accumulation;summary of methods of separation and extraction,qualitative and quantitative detection,and artificial synthesis of kinsenoside;pharmacological effects of kinsenoside,including anti-hyperglycemia,anti-hyperliposis,hepatoprotection and relieve bone lesions,etc.Considering that the raw material resources of kinsenoside are scarce and the market application is limited due to high labor costs,we believe that by improving the extraction efficiency of kinsenoside in the genus Anoectochilus,developing more plants containing kinsenoside,or the improvement of cultivation efficiency and artificial synthesis technology,and other methods to solve production practice problems.In terms of pharmacological research,we support the use of dose toxicity tests on large primates,the development of targeted therapy strategies to improve the accuracy of treatment,and the precise intervention time points for the use of kinsenoside which lay the foundation for translational application in future clinical practice.

Key words: kinsenoside, extraction, detection, artificial synthesis, pharmacological effects

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