Abstract: The objective of this study was to evaluate the antioxidant activity of Erigeron breviscapus extract and the protective effect of E.breviscapus extract on pancrea and liver injuries of type 2 diabetes mice.Type 2 diabetes mice model was induced by high-glucose-high-fat diet and small dose of alloxan.The T-SOD activity and MDA concentration of all mice serum were determined by Kit.The morphological changes of pancrea and liver tissues in mice were observed under light microscope.The results showed that the extracts of E.breviscapus can significantly increase the T-SOD activities of type 2 diabetes mellitus serum (P<0.05),and obviously decrease the concentration of MDA (P<0.05).The difference between their pathological injuries was significant(P<0.05),the model group was obviously higher than those of the other groups.It indicated that the extracts of E.breviscapus had significant antioxidant effect and had some protective effects on pancrea and liver injuries of type 2 diabetes mice.

Key words: Erigeron breviscapus extract, T-SOD, MDA, type 2 diabetes mice