Abstract: To study the effect of Xiaoke Tongmai capsule crude drug on acute toxicity in mice after intragastric administration.The maximum quantity was determined according to the design of pilot test.Forty mice were randomly divided into the treatment group and negative control group.For the treatment group,Xiaoke Tongmai capsule crude drug,with 1875 g/kg as maximum drug dose and 30 mL/kg as maximum drug volume,is administrated three times in 24 h,while for the negative control group,distilled water is adopted.The accumulated dose was 56.25 g/kg.After administration,mice were free to forage and drink for 2 weeks,and the bodyweight,behavior and death were recorded.No abnormality in bodyweight and behavioral activity was observed in the treatment group.No death was discovered. Under this experimental condition,the dose of 56.25 g/kg is the maximum dose of Xiaoke Tongmai capsule crude drug.It was about 203.85 g crude drug and 102 times of the clinic dose.

Key words: acute toxicity test, maximum dose, Xiaoke Tongmai capsule crude drug