Study on Optimization of Ultrasonic-assisted Extraction of Total Flavonoids from Rubus corchorifolius L.f by response Surface Analysis

Abstract

Abstract: Response surface methodology（RSM）was applied to optimize ultrasonic-assisted extraction process of total flavonoids from Rubus corchorifolius L.f.Based on single experiments,extraction times,the concentration of ethanol and ultrasonic temperature were selected for BoxBehnken central composite design.RSM was employed to study the effect of these factors on the yield of total flavonoids.The results indicated that the optimal process conditions were to extract 2 times,76% of aqueous ethanol，with 44 ℃ of ultrasonic temperature.Under these optimized conditions,the extraction yield of total flavonoids was up to 12.39 mg/g.

Key words: Rubus corchorifolius L.f, total flavonoids, ultrasonic-assisted extraction, response surface methodology

CLC Number:

R932

WANG Yu-wei1,2, YANG Yong-jing1,2, HU Na1,2, SUO You-rui1*. Study on Optimization of Ultrasonic-assisted Extraction of Total Flavonoids from Rubus corchorifolius L.f by response Surface Analysis[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(Suppl1): 128-132.

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Study on Optimization of Ultrasonic-assisted Extraction of Total Flavonoids from Rubus corchorifolius L.f by response Surface Analysis

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