This study used the method of network pharmacology to study the multi-component，multi-target and multi-pathway mechanism of Qingfei Paidu Decoction in the treatment of COVID-19，in order to provide basis for related basic research and clinical application.First of all，according to the screening conditions of OB ≥ 30% and DL ≥ 0.18，302 active components and 148 related targets in Qingfei Paidu Decoction were screened by TCMSP database，screening of 362 COVID-19 -related targets by GeneCards database，23 intersection targets were obtained by Venn analysis.Then 10 significant effective compounds and 5 key targets were obtained by using the CentiScaPe plug-in of Cytoscape software，Further construct the network topology diagram.The results of molecular docking of significant effective compounds and key targets show that the binding ability and interaction ability between molecules are strong.Finally，the GO and KEGG pathway enrichment analysis of the key targets were done through the ClusterProfiler package of R software，key compounds such as quercetin，luteolin，naringin，kaempferol and baicalein have antitussive，expectorant，anti-inflammatory and antiviral effects to varying degrees，the key targets are mainly concentrated in 144 related signal pathways such as IL-17，Tuberculosis，TNF，MAPK，Th17，Pertussis，etc.It involves 28 biological functions such as phosphatase binding，MAP kinase activity and cytokine receptor binding to regulate metabolism，immune regulation，inflammation and other physiological processes.According to the above results，it is considered that the active components of Qingfei Paidu decoction have multi-target and multi-pathway regulating effect on the treatment of COVID-19.