Abstract:

Perillae Fructus is a traditional Chinese herbal medicine,which is widely used in Chinese medicine clinics.It contains a variety of chemical components,including volatile oils,fatty acids,flavonoids,phenolic acids,phytosterols,etc.It has a variety of pharmacological effects,such as anti-cough and anti-asthma,antibacterial,anti-allergic,hypolipidemic,hypoglycemic,anti-cancer,anti-aging,and memory enhancement.In this paper,the chemical composition and pharmacological effects of Perillae Fructus were summarized,and combined with the concept of quality marker (Q-Marker) in traditional Chinese medicine.The Q-Markers of Perillae Fructus were comprehensively predicted and analyzed from the perspectives of plant affinity and compositional peculiarities,traditional medicinal properties,the correlation between chemical composition and clinical application,different processing methods,measurability of components,different compounding environments and so on.The results suggested that rosmarinic acid,caffeic acid,luteolin,apigenin,α-linolenic acid and dihydro cuminyl alcohol could be used as the Q-Markers of Perillae Fructus,which could provide the basis for the improvement of the pharmacological material basis of Perillae Fructus and the quality evaluation system.

Key words: Perillae Fructus, Q-Marker, flavonoids, phenolic acids, fatty acids, volatile oils