Ginkgo biloba Extract Release Agent Acupoint Embedding Therapy Attenuates the Injury of Cerebral Ischemia/Reperfusion through Nrf2/HO-1 Signal Pathway

doi:10.16333/j.1001-6880.2017.1.005

Abstract

Abstract: The aim of this study was to observe the effects of Ginkgo biloba extract release agent acupoint embedding (GBER) therapy on brain injury and Nrf2/HO-1 signal pathway after cerebral ischemia/reperfusion in rats.Cerebral ischemia/reperfusion rat model was induced by the modified middle cerebral artery occlusion model (MCAO) method.The neurological deficit score and histopathological examination of hippocampal CA1 were performed.The levels of malondialdehyde (MDA),nitric oxide (NO),superoxide superoxide dismutase (SOD) and glutathione (GSH) were assayed.Nrf2/HO-1 mRNA and protein expressions of brain tissue were detected.The results showed that G.biloba extract sustained-release agent significantly increased the neurological deficit score,the number of neurons.GBER not only reduced the content of MDA and NO,but also augmented the activity of SOD and the content of GSH.The mRNA and protein of Nrf2/HO-1 in GBER group enhanced.These findings showed that GBER therapy attenuated the injury of cerebral ischemia/reperfusion via regulating Nrf2/HO-1 signal pathway.

Key words: cerebral ischemia, reperfusion injury, Ginkgo biloba extract, acupoint embedding, Nrf2, HO-1

CLC Number:

R284.2

YANG Jing1*,WU Feng-zhi2,LI Yu-xia3,ZHANG Dong-sen3. Ginkgo biloba Extract Release Agent Acupoint Embedding Therapy Attenuates the Injury of Cerebral Ischemia/Reperfusion through Nrf2/HO-1 Signal Pathway[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2017, 29(1): 27-33.

[1]	REN Peng, LIN Dan-dan, NIE Yu, WANG Yi-feng, DONG Shi-wen, WANG Bo-yuan. Protective effect of oligomeric proanthocyanidins on the exercise-induced myocardial injury in rat and its mechanism [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(8): 1401-1408.
[2]	FAN Zeng-guang, YUAN Ye, OUYANG Xiao-qiang, ZHAO Yong-fa. Study on the mechanism of modified Buyang Huanwu Decoction in preventing and treating atherosclerosis through Nrf2/ARE pathway [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(4): 644-652.
[3]	XU Yuan-qing, ZHANG Jing, WANG Zhe-qi, HONG Lei. Alleviating effect of fucoidan on oxidative stress in rats [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(4): 653-659.
[4]	WANG Xiao-lan, LI Fang, SUN Mo, WANG Xiao-yang, FENG Wei-sheng. Protective effect of allantoin from Dioscoreae Rhizoma on cyclophosphamide-induced premature ovarian failure in rats [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2023, 35(12): 2137-2144.
[5]	XIE Feng, DUAN Guang-jing, LI Min, LAN Wei. Study on the mechanism of Aconiti Lateralis Radix Preparata-Zingiberis Rhizoma in treating myocardial ischemia-reperfusion injury based on network pharmacology and experimental verification [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2023, 35(1): 151-158.
[6]	LIU Jia-li, REN Wei, YANG Si-jin, TANG Run, MAO Lin-shen, SHUI Pi-xian. Study on the effective ingredients and potential mechanism of Sargentodoxa cuneata in the treatment of cerebral infarction based on UPLC-HR-MS and network pharmacology [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(3): 436-447.
[7]	LIAO Jiang-min, ZHU Tong, YANG Xue-feng, LENG Chong-jiao, YANG Jun-xuan. Study on the protective effect of Codonopsis Radix on oxidative damage based on network pharmacology [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(12): 2110-2118.
[8]	YANG Si-qi, ZHANG Chang-cheng, MA Qiong-yan, YOU Xu, YANG Yuan, ZHANG Yan, YUAN Ding, ZHAO Hai-xia. Protective effect of icariin on D-galactose induced 15P-1 cells injury via Nrf2 signaling pathway [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(4): 577-584.
[9]	TAN Jia-ni, LIU Wen-hao, SHEN Wei-xing, SUN Dong-dong, CHENG Hai-bo. The anti-proliferative activity and mechanism exploration of 2-hydroxyl group-3-tectoquinone on colon cancer cells [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(2): 268-274.
[10]	SULIYAN Sai-li-mu-jiang, YIMURAN Ma-rui-shi, CONG Yuan-yuan, AYIJIANG Ha-bai-ke, PALIDA A-bu-li-zi. Effect of Fomes officinalis Ames polysaccharides on Nrf2/ARE signal pathway in AD rat model induced by Aβ_1-42 [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(1): 89-96.
[11]	CHENG Mao-jun, GUO Jie, LIU Jing, XIE Sai-sai, . Research progress of Nrf2 and natural product-oriented Nrf2 activator [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(1): 165-177.
[12]	AYIJIANG Ha-bai-ke, WANG Xiao-mei, YAN Dong, LI Min, PALIDA A-bu-li-zi. Trace Aβ_25-35 subcellular localization by targeting probes and explore Nrf2 pathway-based protective mechanism of mitochondrial damage of Fomes officinais Ames polysaccharides [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2020, 32(7): 1213-1218.
[13]	QIN Fei-zhang, DONG Min, QIN Qiu-hua, XUAN Fei-fei, HUANG Yuan-heng. 17-Methoxyl-7-hydroxyl-benzofuran chalcone activates Nrf2/ARE pathway to protect H9c2 cells against apoptosis [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2020, 32(6): 1038-1044.
[14]	XU Fei-fei, LI Qin-qing, CHU Shi-feng, HE Wen-bin. Research progress on the neuropharmacological effects and mechanisms about the main components α- and β-asarone in volatile oils of Acorus [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2020, 32(11): 1969-1979.
[15]	XU Qiong-mei, GAO Ya, LI Zi-meng, WEI Ri-ming, MA Xiao-hui, JIN Ling, ZHANG Ke-feng. The effect of gentiopicroside on TLR-4/NF-κB and AMPK/Nrf2 in non-alcoholic fatty liver disease [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2020, 32(10): 1652-1658.

Ginkgo biloba Extract Release Agent Acupoint Embedding Therapy Attenuates the Injury of Cerebral Ischemia/Reperfusion through Nrf2/HO-1 Signal Pathway

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments