In this work,an UPLC method was developed for the simultaneous determination of 8 components in Angelica sinensis in Gansu Province.Chromatographic separation was performed on a Waters ACQUITY UPLC BEH C₁₈ column (2.1 mm×50 mm,1.7 μm) through a gradient delivery of a mixture of methanol and 1% acetic acid at a flow rate of 0.3 mL/min.The column temperature was maintained at 30 ℃,and the detection wavelength was set at 270 nm.The results of method validation showed that the RSDs of reproducibility,stability,precision and recovery were all less than 3%,and all of the analytes exhibited good linearity (R²>0.999) in a relatively wide concentration range.Principal component analysis was further applied to study the comprehensive quality of Angelica sinensis in different producing areas and the results suggested that the quality of Angelica sinensis in Dingxi City was better than that in other cities.In addition,the contents of chlorogenic acid,senkyunolide A and ligustilide fluctuated greatly for different areas,which had great influence on the quality of Angelica sinensis.The obtained findings provided a theoretical basis for the quality evaluation of Angelica sinensis in Gansu Province.