α-Glucosidase Inhibitors from Cinnamomi Cortex

doi:A

Abstract

Abstract: To search α-glucosidase inhibitors from Cinnamomi Cortex, the α-glucosidase inhibitor was isolated and purified by the bioactivity-guided method in vitro, combined with HPLC method which was used to analysis the inhibitory activity against α-glucosidase. The inhibitory kinetic of the isolations was also investigated. The petroleum ether extract showed strong inhibitory activity (IC50=350.37 μg/mL), which was higher than that of acarbose (IC50=1028.99 μg/mL), and two active compounds were isolated and identified as trans-cinnamaldehyde (IC50=277.89 μg/mL) and cinnamic acid (IC50=286.22 μg/mL). Both of them showed noncompetitive type manner on α- glucosidase with Ki value of 178.07 μg/mL and 229.43 μg/mL, respectively.

Key words: Cinnamomi Cortex, α-glucosidase, HPLC, inhibitor, inhibitory type

CLC Number:

R932

XU Qin-yong, ZHU Jing-bo, WANG Zhen-zhong, XIAO Wei. α-Glucosidase Inhibitors from Cinnamomi Cortex[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(09): 1246-.

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