NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (9): 1393-1397.

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Chemical Constituents of Endophytic Fungi Shiraia sp.Slf14 from Huperzia serrata and Their Antibacterial Activity

YAN Ri-ming1,2, LI Xi-xi2,3, WANG Ya1,4, YU Jia-qing2, ZHANG Zhi-bin2, ZHU Du2,4*   

  1. 1 Key Laboratory for Research on Active Ingredients in Natural Medicine of Jiangxi Province,Yichun University,Yichun 336000, China; 2 Key Lab of Protection and Utilization of Subtropic Plant Resource of Jiangxi Provinces,Nanchang 330022, China; 3 Science and Technology College of Jiangxi University of Traditional Chinese Medicine,Nanchang 330025, China; 4 Key Lab of Bioprocess Engineering of Jiangxi Province, College of life sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, China
  • Online:2014-09-30 Published:2014-11-02

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Abstract: Nine compounds were isolated and purified from the petroleum ether and ethyl acetate extract of endophytic fungi Shiraia sp.Slf14 of Huperzia serrata by various chromatographic methods,and their structures were elucidated as eburicol (1), 2,3-dihydroxypropyl 9Z,12Z-octadecadienoate (2), (R)-2,3dihydroxypropyl stearate (3), 2,3-dihydroxypropyl hexadecanoate (4), hypocrellins A (5), hypocrellins B (6), elsinochromes B (7), elsinochromes C (8) and linoleic acid (9) by ESI-MS and NMR. Among them, compounds 1-4, 7 and 9 were firstly isolated from this genus. In addition,seven compounds were firstly detected and identified as 1-methyl-2-pyrrolidinone, pentadecanoic acid thyl ester,ethyl 9-hexadecenoate,hexadecanoic acid ethyl ester,9,12-octadecadienoic acid ethyl ester, (E)-9-octadecenoic acid ethyl ester and octadecanoic acid ethyl ester in petroleum ether extract using GC-MS.Compounds 2-5 showed antibacterial activity against the indicator microorganisms.

Key words: endophytic fungi, chemical constituents, structural elucidation, antibacterial activity

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