NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (1): 148-152.doi: 10.16333/j.1001-6880.2015.01.030

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Protective Effects of Lycium ruthenicum Murr on X-Radiation Injured Mice

DUAN Ya-bin1, YAO Xing-cheng1, WANG Cai2, CHEN Xiang-hong1, ZHANG Juan-ling1, LI Xiang-yang1*   

  1. 1 Medical College of Qinghai University;2 QingHai University Affiliated Hospital,Qinghai Xining 810001,China
  • Online:2015-01-31 Published:2015-02-12

Abstract: To study the protective effects of Lycium ruthenicum Murr extract against radiation-induced damage on mice.Except the normal control group,mice of other groups were received with 5 Gy of X-radiation.Red blood cell count (RBC),white blood cell count (WBC),platelet count (PLT),hemoglobin count (HGB),thymus index and spleen index,activity of various antioxidant enzymes,DNA and caspase-3,caspase-6 content were observed at 7 d after radiation.The results showed that L.ruthenicum extract significantly increased quantity of hemogram,activity of SOD,content of DNA in bone marrow.The activity of CAT,GSH-PX,T-AOC and the content of caspase-3,caspase-6 significantly reduced.In addition,the spleen index,thymus index had no statistical significance in our study.These results indicated that L.ruthenicum had protective effects on mice radiation damage.

Key words: Lycium ruthenicum Murr, anti-radiation, scavenging free radicals, antioxidant activity

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