Abstract: To study the protective effects of Lycium ruthenicum Murr extract against radiation-induced damage on mice.Except the normal control group,mice of other groups were received with 5 Gy of X-radiation.Red blood cell count (RBC),white blood cell count (WBC),platelet count (PLT),hemoglobin count (HGB),thymus index and spleen index,activity of various antioxidant enzymes,DNA and caspase-3,caspase-6 content were observed at 7 d after radiation.The results showed that L.ruthenicum extract significantly increased quantity of hemogram,activity of SOD,content of DNA in bone marrow.The activity of CAT,GSH-PX,T-AOC and the content of caspase-3,caspase-6 significantly reduced.In addition,the spleen index,thymus index had no statistical significance in our study.These results indicated that L.ruthenicum had protective effects on mice radiation damage.

Key words: Lycium ruthenicum Murr, anti-radiation, scavenging free radicals, antioxidant activity