NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (2): 180-181.

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A New Isocoumarin Compound from Marine-derived Fungus Hansfordia sinuosae

WANG Hui-jun,SHI Wen-si,ZHU Hua-jie*   

  1. School of Pharmacy,Hebei University,Hebei Baoding 071002,China
  • Online:2016-02-29 Published:2016-03-07

Abstract: Chemical constituents of fermentation broth of marine-derived fungus Hansfordia sinuosae were studied using column chromatography,semi-preparative HPLC,ODS column chromatography and Sephadex LH-20 column chromatography,respectively.Three isocoumarin compounds were obtained.Based on 1D NMR,2D NMR,high resolution MS and IR analyses,their structures were elucidated as (E)-6,8-dihydroxy-3-(prop-1-en-1-yl)-1-H-isochromen-1-one (1),(R)-6-hydroxymellein (2),3-methyl-6,8-dihydroxyisocoumarin (3).Compound 1 is a new compound,and compound 3 is isolated from this genus of fungus for the first time.

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