Isolation and screening of actinomycetes to produce antibiotic metabolites from Beibu Gulf nearby Guangxi

doi:10.16333/j.1001-6880.2019.7.008

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2019, Vol. 31 ›› Issue (7): 1170-1176.doi: 10.16333/j.1001-6880.2019.7.008

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Isolation and screening of actinomycetes to produce antibiotic metabolites from Beibu Gulf nearby Guangxi

WANG Cong1*,WANG Kun1,JIANG Ming-guo2,TAN Xue-cai1,LEI Fu-hou1,DU Fang-kai1,QIU Zi-yan1,SUN Kun-lai3

1Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,School of Chemistry and Chemical Engineering,Guangxi University for Nationalities; 2Guangxi Colleges and Universities Key Laboratory of Utilization of Microbial and Botanical Resources,School of Marine Sciences and Biotechnology,Guangxi University for Nationalities,Nanning 530006,China; 3Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products,School of Food and Pharmacy,Zhejiang Ocean University,Zhoushan 316022,China

Online:2019-07-29 Published:2019-07-29

Abstract

Abstract: To isolate marine actinomycetes from Beibu Gulf nearby Guangxi soil and plants,and to screen antibiotic actinomycete strains,and to isolate active compounds.The isolation of actinomycetes was performed by normal methods,the screening of active fermentation products was preceded by antibacterial assays,the isolation of compounds were performed by bioassay-guided method,the structure of compound was elucidated through the spectroscopic analysis.The results showed that 73 actinomycetes strains were isolated from Beibu Gulf nearby Guangxi soil and plants,7 of which showed antimicrobial activities against Fusarium oxysporum f.sp.cubense,Staphylococcus aureus.And staurosporin was identified from the secondary metabolites of Streptomyces sp.MDCW-126.Actinomycetes from Beibu Gulf nearby Guangxi are potential resources for active strains and need further study.

Key words: Beibu Gulf nearby Guangxi, actinomycetes, antimicrobial activity, staurosporin

CLC Number:

WANG Cong1*,WANG Kun1,JIANG Ming-guo2,TAN Xue-cai1,LEI Fu-hou1,DU Fang-kai1,QIU Zi-yan1,SUN Kun-lai3. Isolation and screening of actinomycetes to produce antibiotic metabolites from Beibu Gulf nearby Guangxi[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(7): 1170-1176.

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Isolation and screening of actinomycetes to produce antibiotic metabolites from Beibu Gulf nearby Guangxi

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